Multistage Sampling for Disease Family Registries
نویسندگان
چکیده
منابع مشابه
Multistage sampling for disease family registries.
BACKGROUND The objectives of a family-based disease registry range from characterizing measured genetic factors and gene-environment interaction effects to detecting novel susceptibility genes. Gathering complete information on exposure and disease status in all family members for a sample of affected subjects (probands) to address these diverse objectives would be prohibitively expensive. ME...
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In the past, to study Mendelian diseases, segregating families have been carefully ascertained for segregation analysis, followed by collecting extended multiplex families for linkage analysis. This would then be followed by association studies, using independent case-control samples and/or additional family data. Recently, for complex diseases, the initial sampling has been for a genome-wide l...
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ژورنال
عنوان ژورنال: JNCI Monographs
سال: 1999
ISSN: 1052-6773,1745-6614
DOI: 10.1093/oxfordjournals.jncimonographs.a024225